X0508 4 2025-09-18 0 0001599298 Summit Therapeutics Inc. SMMT 0001890784 Anand Bhaskar C/O SUMMIT THERAPEUTICS INC. 601 BRICKELL KEY DRIVE, SUITE 1000 MIAMI FL 33131 0 1 0 0 Chief Accounting Officer 0 Stock Option (right to buy) 19.23 2025-09-18 4 A 0 50000 A 2035-09-18 Common Stock 50000 50000 D The option was granted on September 18, 2025. The shares underlying the option shall vest in four equal annual installments, with the first such installment occurring on September 18, 2026. Not applicable. /s/ Bhaskar Anand 2025-09-19